FORC3® safety data published

Axitan’s manuscript evaluating the safety of its lead product FORC3® has just been published by the international journal Avian Diseases. 

Feed additives are critical components for poultry health and the economic viability of antibiotic-free poultry production. The aim of this study was to evaluate the safety of a novel algal-derived feed additive, a dried biomass powder produced from Chlamydomonas reinhardtii, modified to express an N-acetylmuramoyl-L-alanine amidase and a lysozyme-type enzyme. A 42-day oral toxicity study showed that the dried biomass powder was fully tolerated by broiler chicken with no detrimental effects found in performance, mortality, hematology, blood clinical chemistry, and histopathological results compared with a non-treated control group, resulting a No Observed Adverse Effect Level (NOAEL) of 5000 ppm, the highest dose tested.

The study demonstrates the first-ever safety result of a C. reinhardtii microalgae dried biomass powder used as a feed additive in broiler chickens. Furthermore, safety is shown for the two additional enzymes expressed within the C. reinhardtii strain and ingested by the birds.

For access to the full manuscript please visit the following link here 

(or paste into your browser: https://doi.org/10.1637/aviandiseases-D-22-00043)